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Aufgaben: Establish, characterise and maintain patient-derived cancer cell lines and 3D organoids, including models derived prospectively from fresh tumour biopsies • Perform in vitro efficacy studies and mechanistic validation experiments, using drug response, clonogenic growth and live-cell imaging assays • Design and carry out genome-wide CRISPR/Cas9 synthetic lethality screens and validate the resulting druggable hits • Analyse screening and sequencing data using established bioinformatics pipelines (MAGeCK RRA/MLE, R) • Perform confocal and multiplexed immunofluorescence microscopy • Contribute to in vivo xenograft experiments and to the histological and computational pathology characterisation of explanted tumours • Present results at national and international conferences and prepare first-author manuscripts for peer-reviewed journals • Participate in the doctoral programme of the Graduate School for Cellular and Biomedical Sciences
Anforderungen: Master's degree (MSc) in Molecular Life Sciences (Cell and Molecular Biology or Biochemistry/Chemical Biology), Biomedical Sciences, molecular biology, biochemistry, biotechnology or a related field, completed by the starting date, ideally with at least one full year lab experience. • Solid practical experience in mammalian cell culture (experience with 3D organoids is an advantage) • Experience in standard molecular biology and imaging techniques (western blotting, immunofluorescence, qPCR, optical microscopy). Experience with confocal microscopy is an advantage • Basic skills in data analysis and statistics; familiarity with GraphPad or R is an advantage • Strong motivation for translational cancer research and genuine interest in bridging laboratory work and clinical questions • Ability to work collaboratively within an interdisciplinary and multicentric team • Excellent command of English, written and spoken
Wir bieten: Strong research infrastructure and international network
Stellenantritt: 01.02.2027 or by agreement
Pensum: Full-time, Half-time possible
Bewerbungsfrist (laut Anzeige): 15.11.2026